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Monday, May 11, 2020 | History

5 edition of Tenascin found in the catalog.

Tenascin

Prashanta Shrestha

Tenascin

An Extracellular Matrix Protein in Cell Growth, Adhesion and Cancer (Molecular Biology Intelligence Unit)

by Prashanta Shrestha

  • 304 Want to read
  • 16 Currently reading

Published by Chapman & Hall .
Written in English


The Physical Object
Number of Pages213
ID Numbers
Open LibraryOL7478305M
ISBN 100412148617
ISBN 109780412148613
OCLC/WorldCa37213976

Tenascin C expression correlates with tumor grade and indicates worse prognosis in several tumors. Epidermal growth factor receptor (EGFR) plays an important role in driving proliferation in many tumors. Loss of E-cadherin function is associated with tumor invasion and metastasis. Thyroid transcription factor-1 (TTF-1) is involved in rearranged during transfection (RET) Cited by: 5. Tenascin finds in vertebrates, the family of a high conservative of larger polymer extracellular matrix (ECM) Mammals, identify four kinds of tenascin paralog things (paralogue), be called tenascin-C, tenascin-R, tenascin-X and primary structure that the tenascin family protein is common, it comprises seven Cited by:

Search the world's information, including webpages, images, videos and more. Google has many special features to help you find exactly what you're looking for. Here we focus on the progress in our understanding of how one component of the tumor soil, tenascin-C, is responsible for promoting the survival of primary tumor cells. We also review data that reveal a new role for tenascin-C in promoting tumor angiogenesis and enabling the migrating metastatic cancer cell to thrive at secondary tumor : Falk Saupe; Anja Schwenzer; Kim Midwood.

  Tenascin (TN) is a large oligomeric glycoprotein that is present transiently in the extracellular matrix (ECM) of cells and is involved in morphogenetic movements, tissue patterning, and tissue repair. It has multiple domains, both adhesive and anti-adhesive, that interact with cells and with fibronectin (FN) and other ECM macromolecules. Molecular Biology of the Cell Vol. 7, No. 6 Research Article Free Access Mitogenesis, cell migration, and loss of focal adhesions induced by tenascin-C interacting with its cell surface receptor, annexin II.


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Tenascin by Prashanta Shrestha Download PDF EPUB FB2

Tenascin-W is found in the kidney and in developing bone. The basic structure is 14 EGF-like repeats towards the N-terminal end, and 8 or more fibronectin-III domains which vary upon species and variant.

Tenascin-C is the most intensely studied member of the family. Tenascin C in Breast Cancer and millions of other books are available for Amazon Kindle. Learn more. Share Read this book and over 1 million others with a Kindle Unlimited membership. Read with Kindle Unlimited Buy New. $ Qty: Qty: 1. Author: Stefan Swierczynski MSc.

M Benjamin, J.R Ralphs, in International Review of Cytology, 1 Tenascin-C. Tenascin-C is a large, multifunctional ECM glycoprotein with a hexameric structure.

Its expression in a variety of tissues is often transient and restricted during embryonic development, but it can be reexpressed in adults during both normal and pathological tissue remodeling (Jones and Jones, ). Brian K. Hall, in Bones and Cartilage (Second Edition), Tenascin, which is located in chondrogenic condensations, perichondria, osteogenic cells and differentiated cartilage and bone, plays a key role in mesenchymal cell condensation (Chapter 19).Tenascin also is present in embryonic epithelia, including the neural epithelium as NCC emerge, and in the extracellular.

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Tenascin and Counteradhesive Molecules of the Extracellular Matrix book. Read reviews from world’s largest community for readers. Tenascin and Counteradh Ratings: 0.

Tenascin-C, tenascin-R, Tenascin book tenascin/J1 were all expressed in the olfactory bulb and spinal cord during development, while tenascin/J1 was the only Author: Gertraud Orend. ISBN: OCLC Number: Description: xii, pages: illustrations. Contents: Molecular biology of tenascin: structure, splice variants, and regulation of gene expression / Frederick S.

Jones and Donald W. Copertino --Role of tenascin domains in developmental patterning, cell migration and gene expression / Kathryn L. Crossin, Anne L. Tenascin C (TN-C) is a glycoprotein that in humans is encoded by the TNC gene. It is expressed in the extracellular matrix of various tissues during development, disease or injury, and in restricted neurogenic areas of the central nervous system.

Tenascin-C is the founding member of the tenascin protein family. Zebrafish tenascin‐C shares structural homologies with tenascin‐C molecules of other vertebrate species. The deduced amino acid sequence of zebrafish tenascin‐C is aligned with human, mouse, and chicken tenascin‐C.

Regions containing epidermal growth factor‐like repeats (EGF‐like repeats), fibronectin type III‐like domains (FNIII‐like domains), and the fibrinogen Cited by: Exploiting High Tenascin-C Expression in Cancer for Diagnosis and Targeting.

Here, we focused on how the expression of tenascin-C could be exploited for diagnosis and targeting because tenascin-C is highly expressed in cancer tissue where it can correlate with poor prognosis and tumor progression.

2,3 Formal evidence of its tumorigenesis promoting activity has recently. A similar phenotype was observed in tenascin-C-deficient mice, suggesting that periostin is associated with tenascin-C to elaborate an ECM meshwork architecture that includes fibronectin and type I collagen (Fig.

This architecture generates a microenvironment for mechanical stress-dependent bone formation. Several members of the tenascin gene family have been described. They represent large multimeric extracellular matrix proteins, each of them consisting of identical subunits built from variable numbers of repeated domains.

They have variety of actions including antiadhesive function and promotion of neurite outgrowth. Regeneration of Optic Nerve.

Tenascin-C (TN-C) is an extracellular matrix protein which participates in different processes like normal fetal development, wound healing, inflammation, keloids and rheumatoid arthritis. Furthermore, the immunostaining for TN-C is seen in the stroma of various malignant tumors as in glioblastoma multiforme (GBM), however, the significance of Cited by: Tenascin knock out mice suggest that it is a redundant protein with as of yet no unique purpose.

References Cecil RL, Bennett JC, Goldman L (eds) () Cecil Textbook of Medicine, 21st ed. WB Saunders, Philadelphia Google Scholar. Tenascin-C is characterized by a distinct domain organization. An assembly domain at the N-terminus, responsible for the formation of the six-armed oligomer known as the hexabrachion, is followed by a series of epidermal growth factor-like (EGF-L) repeats, constitutively expressed and alternatively spliced fibronectin type III-like repeats (FNIII), and a C-terminal fibrinogen-like Cited by: 8.

tenascin (plural tenascins) (biochemistry) Any of a class of glycoprotein found in the extracellular matrix of developing vertebrate embryos; Anagrams. ancients, canniest, cantines, catenins, insectan, instance.

A cDNA clone encoding tenascin-W, a novel member of the tenascin family, was isolated from a to h postfertilization (hpf) zebrafish cDNA library on. COVID Resources.

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@article{osti_, title = {Tenascin-X, Collagen, Elastin and the Ehlers-Danlos Syndrome}, author = {Bristow, James and Carey, William and Schalkwijk, Joost}, abstractNote = {Tenascin-X is an extracellular matrix protein initially identified because of its overlap with the human CYP21B gene.

Because studies of gene and protein function of other tenascins had been poorly. fig1: Morphological changes of MCF-7 cells grown on a tenascin-C substratum.

MCF-7 cells were cultured for 24 h in complete medium on fibronectin-coated (A) and on tenascin-C–coated (B) dishes and photographed. On fibronectin, they adopt a cobble-stone–like epithelial morphology, whereas on tenascin-C they lose the cell–cell contacts and adopt irregular shapes.

Ihida-Stansbury K, McKean DM, Lane KB, et al. Tenascin-C is induced by mutated BMP type II receptors in familial forms of pulmonary arterial hypertension. Am J Physiol Lung Cell Mol Physiol. ; L–LCited by: Tenascin-X is an extracellular matrix protein initially identified because of its overlap with the human CYP21B gene.

Because studies of gene and protein function of other tenascins had been poorly predictive of essential functions in vivo, we used a genetic approach that critically relied on an understanding of the genomic locus to uncover an association between inactivating .